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DOE Modelling and Optimization of Tablet Coater Mechanism


Author(s):

Poonam Sanju Gaikwad , VIT Pune; Prof. M.R.Khodke, VIT Pune

Keywords:

Coating, Spray ARM, Gun to Bed Distance, Spray Rate, DOE

Abstract:

Tablet coating is one of the Pharmaceutical Process in which coating material is being sprayed on granulated tablets. There are several types of equipment used in order to coat the tablets. Among them the one with perforated pan is quite effective in order to get proper flow of air when there is simultaneous process of spraying wetting and drying. The coating of the tablets in the pharmaceutical industry generally involves many factors but in this DOE modelling three main factors have been considered related to spray arm mechanism This work aimed to development and doe analysis of tablet coater SC700 and optimization using factorial design. The factors consider were: 1. Gun to bed distance (cm) 2. Spray rate (gm/min) 3. Pattern air pressure(bar).


Other Details:

Manuscript Id :IJSTEV2I11316
Published in :Volume : 2, Issue : 11
Publication Date: 01/06/2016
Page(s): 864-868
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